RNA interference-based therapeutics and diagnostics
نویسندگان
چکیده
منابع مشابه
RNA Interference-Based Therapeutics: Harnessing the Powers of Nature
The central dogma of biology describes the transfer of biological information from DNA through to protein (Crick, 1970). In the first phase, known as transcription, DNA is converted into a complementary sequence of messenger RNA (mRNA). This mRNA allows the genetic message to be communicated outside of the nucleus, to other areas of the cell, where it is then translated into protein by ribosome...
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RNA interference is a mechanism for controlling normal gene expression which has recently begun to be employed as a potential therapeutic agent for a wide range of disorders, including cancer, infectious diseases and metabolic disorders. Clinical trials with RNA interference have begun. However, challenges such as off-target effects, toxicity and safe delivery methods have to be overcome before...
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The absence of reliable quantitative laboratory tests for measurements of microRNAs and other classes of small noncoding RNAs in archived, formalin- fixed, paraffin-embedded human samples with sufficient specificity and sensitivity has significantly limited the development of clinically relevant noncoding RNA–based diagnostic and therapeutic applications. A report by Renwick et al. in this issu...
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RNA interference (RNAi) is a sequence-specific, post-transcriptional gene silencing mechanism in animals and plants, which is mediated by double-stranded RNA (dsRNA). There has recently been an increasing interest in harnessing the gene silencing activity of dsRNA to develop novel drugs for the treatment of various diseases, such as cancer, neurol...
متن کاملRNA interference: from gene silencing to gene-specific therapeutics.
In the past 4 years, RNA interference (RNAi) has become widely used as an experimental tool to analyse the function of mammalian genes, both in vitro and in vivo. By harnessing an evolutionary conserved endogenous biological pathway, first identified in plants and lower organisms, double-stranded RNA (dsRNA) reagents are used to bind to and promote the degradation of target RNAs, resulting in k...
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ژورنال
عنوان ژورنال: Drug Delivery and Translational Research
سال: 2013
ISSN: 2190-393X,2190-3948
DOI: 10.1007/s13346-013-0182-7